Fig. 5

A909 fitness data mapped onto transcription factor- and RNA-based regulons. Essential and critical genes involved in transcription factor- (a) and RNA-based (b) regulons are depicted. The center set consists of regulatory genes or RNA regulators predicted to affect transcription of genes in the outer ring. Individual genes are color-coded (green = nonessential, yellow = critical, red = essential, gray = undefined). Transcription factor autoregulatory signaling is denoted with a blue arrow