A missense mutation in TUBD1 is associated with high juvenile mortality in Braunvieh and Fleckvieh cattle

BMC Genomics

Table 1 Harmful effects of two haplotypes with reduced homozygosity in Braunvieh (BH2) and Fleckvieh (BH2_FV) cattle

Haplotype	Chr	Position		Haplotype frequency (%)	Number of calvings		Difference in survival rate
Haplotype	Chr	Start (bp)	Stop (bp)	Haplotype frequency (%)	risk	non-risk	day 2	day 10	day 365	P
BH2	19	10,694,269	11,833,182	6.5	6,299	25,801	−2.1	−3.9	−4.6	1.8x10⁻²⁸
BH2_FV	19	10,406,017	11,453,904	1.7	1,296	45,270	−4.0	−4.0	−6.1	2.2x10⁻¹⁵

The juvenile mortality of calves from risk matings was compared to non-risk matings. Matings between carrier bulls and cows descending from carrier bulls were considered as risk matings and matings between non-carrier bulls and cows descending from carrier bulls were considered as non-risk matings. The difference in survival rate refers to the proportion of additional calf losses in risk compared to non-risk matings. The physical position of the haplotypes was based on the UMD3.1 assembly of the bovine genome

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