Fig. 5

Schematic presentation of the hypothesis concerning expression dynamics of mRNAs and miRNAs during the cell cycle phases in primary untransformed and cancer cells. Relative expression changes in G1, S and G2 phases of a representative cell cycle gene and miRNA in untransformed primary (Panel a) and transformed cancer (Panel b) cells. Relative expression changes of mRNAs exhibiting cell cycle dependent expression (dark blue) and cell cycle associated miRNAs (green) are shown. Blue double arrows mark the amplitude of dynamic expression range in cell cycle phases. Note the different phase-specific expression values and the different dynamic expression range in the two cell types. Upon our results, genes exhibiting cell cycle dependent expression profile in untransformed cells are characterized with lower expression levels throughout the cell cycle, however they possess greater variance in expression levels than in transformed, cancer cells. MiRNAs, however, do not display cell cycle dependent expression