Skip to main content

Table 1 Evolution of docetaxel resistance in MCF-7 cells

From: The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

Docetaxel concentration Passage numbers Days at given concentrationa Subpopulation for analysis Doubling time (Days)
0 (Parental cells) - - MCF-7PAR 1.3
10 pM 1–3 12   
30 pM 4–6 13   
90 pM 7–9 18   
270 pM 10–12 17 MCF-7SUB-0.27nM 1.9
810 pM 13–15 12   
1.2 nM 16–18 69 MCF-7SUB-1.2nM 1.8
1.8 nM 19–21 25   
2.25 nM 22–24 13   
2.8 nM 25–27 19   
3.5 nM 28–30 20   
5 nM 31–33 18   
7.5 nM 34–36 12 MCF-7SUB-7.5nM 1.9
15 nM 37–39 13   
30 nM 40–42 16   
45 nM 43–45 24 MCF-7SUB-45nM 1.8
55 nM 46–48 26   
65 nM 49-   MCF-7RES-65nM 1.4
  1. aNumbers in bold indicate concentration levels at which the cells took more than the average 20 days per concentration step to recover and go through 3 passages