Table 8 Annotation of genes with Class A mutation or CNAs in MDA sub-lines
MDA | MDA | MDA | MDA | MDA |
|---|---|---|---|---|
SUB-0.27nM | SUB-5nM | SUB-15nM | SUB-100nM | RES-150nM |
| Â | Chromatin modification | Nucleotide-binding | Â | Protein dimerization activity |
MSL3, KDM6A, PHF16, KDM4C, RBBP7 | ABCB1, JAK2, RIOK1, CDK16, CDK14, PRKX | NOTCH2, VWF, SLC11A1, DPP4 | ||
Purine nucleoside binding, adenyl nucleotide binding, atp-binding | T cell activation | |||
EPHA5, RPS6KA3, ABCA9, DDX3X, UBA1, MAPK13, CASK, CTPS2, VARS, PRPS2, CLCN4 | CARD11, SLC11A1, DPP4 | |||
Kinase | Transport | |||
EPHA5, RPS6KA3, MAPK13, SH3KBP1, CASK, PRPS2 | SLC11A1, CACNA1I, MFI2, CACNA2D3, AQP7, AQP3 | |||
Regulation of transcription from RNA polymerase II promoter | ||||
CASK, MED14, RBBP7, TBL1X | ||||
Transport | ||||
CLCN4, CCDC64, AP1S2, CASK, ABCA9, ATP5J, APOO |