Fig. 1

The SDP profiles computed for every inhibitor in the kinome dataset. The x-axis represents the residue position in the 27-residue multiple sequence alignment of the binding site. Each row shows the SDPs for one inhibitor whose name is shown on the y-axis. For each inhibitor, blocks with the same color correspond to one of the 3-residue subsets. If there are multiple colors in a given position, then the same residue was part of several selected subsets. This means that the same residue in different structural contexts can help explain the binding affinity of different kinases