Fig. 5

Case study 2 (SP1 knockdown in HeLa cell line). Influence zone of the top 10 epicenters was constructed from the condition-specific highest activity network and enriched with the targets of SP1 and their immediate neighbors. This network was pruned to retain only epicenters, SP1 targets, differentially expressed genes, and the genes connecting them. Nodes with a hexagonal shape represent epicenters, a golden border around the node indicates SP1 target, and a pink border around the node indicates mediator gene. The rank of each epicenter is written next to it in red. (a) SP1 knockdown condition. 14 genes occur in the list of top 10 epicenters (5 genes correspond to rank 5). (b) Control condition. 50 genes correspond to top 10 epicenters. 30 genes correspond to rank 7, and regulate MYC, a target of SP1. Similarly, 9 genes correspond to rank 2, and regulate CEBPB