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Table 1 Automated summary for CD44 (case study 1). CD44 was the 2 nd ranked epicenter specific to the perturbed condition. The table shows the nodes in the immediate influence zone (up to 2 hops up/downstream) of CD44 which showed significant differential expression (2-fold). The first row corresponds to the input node, CD44. In the subsequent rows, the first column shows the differentially expressed gene (DEG). If the DEG is more than 1 hop away from CD44, the intermediate nodes on the unweighted shortest path are described in columns 6 onwards

From: EpiTracer - an algorithm for identifying epicenters in condition-specific biological networks

Node Direction Num_hops Fold_change Which_network Intermediate_node_1 Fold_change Significant_fc? Which_network
CD44 input_node 0 1.0776225906 unique to perturbed CSHAN     
L1CAM down_CD44 2 4.3995043553 unique to perturbed CSHAN EZR 1.4077313131 False common to both CSHANs
CBLB down_CD44 2 2.7450193138 unique to perturbed CSHAN EGFR 0.9625043727 False common to both CSHANs
TNNT1 down_CD44 2 0.3519677136 unique to control CSHAN FYN 1.047836048 False common to both CSHANs
RPS6KA2 down_CD44 2 3.7937197295 unique to perturbed CSHAN EGFR 0.9625043727 False common to both CSHANs
NEDD9 down_CD44 2 0.4699818669 not in any CSHAN FYN 1.047836048 False common to both CSHANs
TFPI down_CD44 2 2.7743880699 not in any CSHAN MMP7 0.1323159054 True not in any CSHAN
MBNL3 down_CD44 2 4.0574758277 not in any CSHAN LCK 0.967172212 False not in any CSHAN
IVNS1ABP down_CD44 2 2.0134951539 common to both CSHANs ARHGEF1 1.0053092034 False not in any CSHAN
ITGB3 down_CD44 2 0.2450269938 not in any CSHAN COL1A2 1.6105271705 False common to both CSHANs
PLA2G4A down_CD44 2 7.496384226 not in any CSHAN COL1A2 1.6105271705 False common to both CSHANs
FN1 down_CD44 2 2.2964207553 unique to perturbed CSHAN COL1A2 1.6105271705 False common to both CSHANs
MEF2C down_CD44 2 2.2667831761 unique to perturbed CSHAN CD74 0.9449408306 False not in any CSHAN
PTK2 down_CD44 2 0.2821339725 not in any CSHAN EGFR 0.9625043727 False common to both CSHANs
CHN1 down_CD44 2 3.1958019401 unique to perturbed CSHAN TGFBR1 0.7284950123 False common to both CSHANs
EGR1 down_CD44 2 2.1681746909 common to both CSHANs ARHGEF1 1.0053092034 False not in any CSHAN
SRGN down_CD44 1 0.4947740703 not in any CSHAN     
OCLN down_CD44 2 2.9381790192 not in any CSHAN TGFBR1 0.7284950123 False common to both CSHANs
ADAM12 down_CD44 2 2.3217184015 unique to perturbed CSHAN IGFBP3 1.9432883668 False common to both CSHANs
TIMP1 down_CD44 2 0.4692561311 unique to control CSHAN MMP1 0.9852575467 False not in any CSHAN
MMP7 down_CD44 1 0.1323159054 not in any CSHAN     
L1CAM up_CD44 2 4.3995043553 unique to perturbed CSHAN ANK1 0.7930398677 False not in any CSHAN
ITGB3 up_CD44 2 0.2450269938 not in any CSHAN COL1A2 1.6105271705 False common to both CSHANs
MMP7 up_CD44 1 0.1323159054 not in any CSHAN