Fig. 2

Assessment of genes with significant outlier pattern through comparison with two well-known cancer gene collections. The Cancer Gene Census (CGC) from the Sanger Institute catalogues genes for which mutations have been causally implicated in cancer; The MSK-Integrated Mutation Profiling of Actionable Cancer Targets (IMPACT™) is a curated panel of key cancer genes used for diagnostic genomic testing. “Union” corresponds to 169 combined genes resulting from the three outlier methods (Fig. 1a)