Table 1 Enriched signatures from the Broad canonical pathway library among outlier genes
Canonical pathway signature | # of outlier genes in the signature | P(enrichment) | FDR |
|---|---|---|---|
KEGG_PATHWAYS_IN_CANCER | 17 | 1.53E-07 | 1.63E-04 |
KEGG_PROSTATE_CANCER | 10 | 2.46E-07 | 1.63E-04 |
KEGG_THYROID_CANCER | 6 | 5.01E-06 | 2.22E-03 |
PID_WNT_CANONICAL_PATHWAY | 4 | 1.05E-05 | 3.25E-03 |
KEGG_ENDOMETRIAL_CANCER | 7 | 1.22E-05 | 3.25E-03 |
PID_BETACATENIN_DEG_PATHWAY | 4 | 3.65E-05 | 7.14E-03 |
KEGG_MELANOMA | 7 | 3.76E-05 | 7.14E-03 |
KEGG_GLIOMA | 7 | 4.44E-05 | 7.38E-03 |
REACTOME_CELL_CYCLE_MITOTIC | 12 | 5.20E-05 | 7.68E-03 |
KEGG_BLADDER_CANCER | 5 | 1.10E-04 | 1.47E-02 |
KEGG_NON_SMALL_CELL_LUNG_CANCER | 6 | 1.56E-04 | 1.88E-02 |
PID_HES_HEYPATHWAY | 5 | 1.76E-04 | 1.88E-02 |
KEGG_COLORECTAL_CANCER | 6 | 1.84E-04 | 1.88E-02 |
REACTOME_SIGNALING_BY_FGFR | 7 | 2.12E-04 | 2.02E-02 |
KEGG_ACUTE_MYELOID_LEUKEMIA | 6 | 2.90E-04 | 2.41E-02 |
PID_SMAD2_3NUCLEARPATHWAY | 6 | 3.35E-04 | 2.47E-02 |
ST_WNT_BETA_CATENIN_PATHWAY | 4 | 3.53E-04 | 2.47E-02 |
BIOCARTA_GSK3_PATHWAY | 4 | 3.53E-04 | 2.47E-02 |
REACTOME_MITOTIC_G2_G2_M_PHASES | 5 | 3.90E-04 | 2.60E-02 |
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE | 7 | 4.24E-04 | 2.68E-02 |
PID_MTOR_4PATHWAY | 6 | 5.70E-04 | 3.29E-02 |
BIOCARTA_G1_PATHWAY | 4 | 5.94E-04 | 3.29E-02 |
SA_G1_AND_S_PHASES | 3 | 6.95E-04 | 3.29E-02 |
REACTOME_G0_AND_EARLY_G1 | 3 | 6.95E-04 | 3.29E-02 |
PID_TCRRASPATHWAY | 3 | 6.95E-04 | 3.29E-02 |
PID_RB_1PATHWAY | 6 | 7.27E-04 | 3.29E-02 |
PID_IL4_2PATHWAY | 5 | 7.61E-04 | 3.29E-02 |
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE | 7 | 7.77E-04 | 3.29E-02 |
KEGG_RENAL_CELL_CARCINOMA | 6 | 8.17E-04 | 3.29E-02 |
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR | 6 | 8.17E-04 | 3.29E-02 |
REACTOME_CELL_CYCLE | 12 | 9.15E-04 | 3.54E-02 |
REACTOME_SIGNALING_BY_ERBB2 | 6 | 1.27E-03 | 4.21E-02 |
KEGG_CHRONIC_MYELOID_LEUKEMIA | 6 | 1.27E-03 | 4.21E-02 |
BIOCARTA_CELLCYCLE_PATHWAY | 3 | 1.44E-03 | 4.55E-02 |
PID_FOXM1PATHWAY | 4 | 1.66E-03 | 4.96E-02 |
REACTOME_SIGNALING_BY_PDGF | 6 | 1.89E-03 | 4.96E-02 |
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS | 3 | 1.94E-03 | 4.96E-02 |
PID_E2F_PATHWAY | 5 | 1.97E-03 | 4.96E-02 |
PID_ER_NONGENOMIC_PATHWAY | 4 | 1.98E-03 | 4.96E-02 |
REACTOME_SIGNALING_BY_EGFR_IN_CANCER | 6 | 2.07E-03 | 5.10E-02 |
BIOCARTA_P53_PATHWAY | 3 | 2.55E-03 | 5.84E-02 |
KEGG_PANCREATIC_CANCER | 5 | 2.77E-03 | 6.14E-02 |
PID_PI3KPLCTRKPATHWAY | 4 | 3.64E-03 | 7.44E-02 |
PID_AR_TF_PATHWAY | 4 | 3.64E-03 | 7.44E-02 |
BIOCARTA_IGF1R_PATHWAY | 3 | 4.07E-03 | 8.07E-02 |
REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | 3 | 4.07E-03 | 8.07E-02 |
KEGG_ERBB_SIGNALING_PATHWAY | 5 | 4.19E-03 | 8.07E-02 |
REACTOME_SIGNALING_BY_SCF_KIT | 5 | 4.61E-03 | 8.63E-02 |
REACTOME_SIGNALING_BY_ERBB4 | 5 | 4.61E-03 | 8.63E-02 |
REACTOME_UNFOLDED_PROTEIN_RESPONSE | 4 | 4.74E-03 | 8.76E-02 |
BIOCARTA_WNT_PATHWAY | 3 | 6.04E-03 | 9.36E-02 |
BIOCARTA_BAD_PATHWAY | 3 | 6.04E-03 | 9.36E-02 |
BIOCARTA_IGF1MTOR_PATHWAY | 3 | 6.04E-03 | 9.36E-02 |
PID_AURORA_A_PATHWAY | 3 | 6.04E-03 | 9.36E-02 |
WNT_SIGNALING | 4 | 6.05E-03 | 9.36E-02 |
PID_AR_PATHWAY | 4 | 6.79E-03 | 0.10 |
REACTOME_SIGNALLING_BY_NGF | 7 | 7.50E-03 | 0.10 |