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Table 2 Outlier genes whose predictive genetic biomarkers are the gene itself (in italic) or from the same gene family/protein complex, suggesting potential oncogenic addiction or a synthetic lethal relationship. Genetic biomarkers and tumor types are listed by decreasing statistical significance of association

From: Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine

Gene Genetic biomarker (related) Tumor type
APC APC CRC
ARID1B ARID1A  
ATP5A1 ATP5H  
BRAF BRAF CRC;Melanoma
CDK2 CCNE1;SKP2 Ovarian;Ovarian_serous_adenocarcinoma;Breast Lum_subtype
CRNN DST;SDF4 ALL;Leukemia/Lymphoma
CTNNB1 APC;PXN;CREBBP CRC
DHX30 PARP1;DHX40 Breast;Breast HER2+;Breast Her2_subtype
E2F1 RB1  
FOXA1 FOXP4 Breast;Breast Lum_subtype;Breast HER2+;Prostate;
Breast BaA_subtype;Prostate_adenocarcinoma;
Breast Her2_subtype;Breast ER+
HNRNPA1 RPL22  
KRAS KRAS Pancreatic;CRC
LRPPRC NFKBIB Breast Lum_subtype;Breast;CRC; Ovarian_clear_cell_adenocarcinoma;Breast HER2+
NRAS NRAS  
PIK3CA PIK3CA Breast;Gastric;Breast Lum_subtype;Gastric_adenocarcinoma; CRC;Breast HER2+;Breast TNBC;Prostate_adenocarcinoma; Breast Her2_subtype;Breast ER+
PSMD3 PSMC4;PSMD8  
RBBP4 ACTL6A;GNB4;WDR89  
RBM47 IGF2BP1;MAK16 Breast HER2+;Breast;Breast Her2_subtype; Esophageal_adenocarcinoma
RBMXL1 MAK16;TAF15  
RPS17 RPL38;RPL22 Ovarian_clear_cell_adenocarcinoma;Ovarian
RREB1 ZNF652;GLI2 Breast;Breast HER2+;Breast Her2_subtype
SF3A3 PRPF3  
SLC25A40 SLC2A3;SLCO1B1;SLCO1A2;SLC2A14;LST-3TM12  
SPEN DHX38;CSTF2T  
TOP2A PARP1;PPM1D;PRKDC Breast;Breast Lum_subtype;Breast HER2+
TOPBP1 NBN;BRCA1  
TUBG1 APC CRC
WDR18 WDR67;GNB2L1;WDR16;NWD1  
ZMIZ1 ZMIZ1 Leukemia/Lymphoma;Breast;AML
ZNF234 ZNF331 Multiple_Myeloma;Ewing_Sarcoma;Leukemia/Lymphoma;Bone
ZNF236 GLI1