Table 2 Pathways that are enriched for the top ranked candidate genes for PD
From: Phenome-based gene discovery provides information about Parkinson’s disease drug targets
Pathway | Description [33] |
|---|---|
BIOCARTA_TRKA_PATHWAY | Nerve growth factor receptor signaling pathway |
BIOCARTA_SPRY_PATHWAY | Regulation of cellular proliferation and differentiation |
BIOCARTA_TFF_PATHWAY | Epithelial repair |
BIOCARTA_ARF_PATHWAY | Tumor Suppressor that inhibits ribosomal biogenesis |
BIOCARTA_LONGEVITY_PATHWAY | Involving age related diseases like neurodegenerative disease |
BIOCARTA_NGF_PATHWAY | Nerve growth factor pathway |
BIOCARTA_HER2_PATHWAY | Mediated signaling of EGFR |
BIOCARTA_BCELLSURVIVAL_PATHWAY | Mediate the survival of B cells |
BIOCARTA_CBL_PATHWAY | Downregulate EGF receptors |
BIOCARTA_CTCF_PATHWAY | Induction of cell cycle arrest and apoptosis |