Table 3 Pathways that are enriched for the top ranked drug target genes
From: Phenome-based gene discovery provides information about Parkinson’s disease drug targets
Pathway | Description [33] |
|---|---|
BIOCARTA_IGF1_PATHWAY | Stimulates cell growth and blocks apoptosis |
BIOCARTA_INSULIN_PATHWAY | Regulation of glucose levels |
BIOCARTA_NGF_PATHWAY | Nerve growth factor pathway |
BIOCARTA_TRKA_PATHWAY | Nerve growth factor receptor signaling pathway |
REACTOME_ACTIVATION_OF_THE_AP1 | Activation of the AP-1 family of transcription factors |
_FAMILY_OF_TRANSCRIPTION_FACTORS | |
BIOCARTA_TFF_PATHWAY | Epithelial repair |
BIOCARTA_LONGEVITY_PATHWAY | Involving age related diseases |
REACTOME_SHC1_EVENTS_IN_EGFR | |
_SIGNALING | EGFR signaling |
BIOCARTA_CBL_PATHWAY | Downregulate EGF receptors |
BIOCARTA_CDK5_PATHWAY | Cellular proliferation and survival |