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Table 3 Pathways that are enriched for the top ranked drug target genes

From: Phenome-based gene discovery provides information about Parkinson’s disease drug targets

Pathway Description [33]
BIOCARTA_IGF1_PATHWAY Stimulates cell growth and blocks apoptosis
BIOCARTA_INSULIN_PATHWAY Regulation of glucose levels
BIOCARTA_NGF_PATHWAY Nerve growth factor pathway
BIOCARTA_TRKA_PATHWAY Nerve growth factor receptor signaling pathway
REACTOME_ACTIVATION_OF_THE_AP1 Activation of the AP-1 family of transcription factors
_FAMILY_OF_TRANSCRIPTION_FACTORS  
BIOCARTA_TFF_PATHWAY Epithelial repair
BIOCARTA_LONGEVITY_PATHWAY Involving age related diseases
REACTOME_SHC1_EVENTS_IN_EGFR  
_SIGNALING EGFR signaling
BIOCARTA_CBL_PATHWAY Downregulate EGF receptors
BIOCARTA_CDK5_PATHWAY Cellular proliferation and survival