Fig. 2

ELM motifs in beta-Catenin. a Distribution of six types of ELM motifs in the N-terminal tail, the ARM domain, and the C-terminal tail. The six types of ELM motifs are: CLV–cleavage site, DEG–degragon, DOC–modifying enzyme docking, LIG–ligand binding, MOD–post-translational modification site, and TRG–subcellular targeting. The density of each type of ELM motif in each region of beta-Catenin was calculated by firstly normalizing the number of a specific type of motifs in that region over the total number of ELM motifs in beta-Catenin, and then scaling the result over the length of that region based on every 100 residues. b and c demonstrate the locations and conservation of ELM motifs in the N- and C-terminal tails, respectively. Motifs in red are experimentally validated. In both figures, “redundant” motifs that belong to the same functional family or overlap with each other on their amino acid sequences have been filtered out to keep the clarity and simplicity of the figures. The weblogo plots were built using beta-Catenin sequences from eight species (Human, Mouse, Bovine, Dog, Turtle, Frog, Jelly fish, and Urchin, see Additional file 2: Table S2)