Table 5 Predictable changes in biological functioning based on DEG analysis in low-RFI individuals
Categories | Functions annotation | P-value | Predicted | Molecules |
|---|---|---|---|---|
Cell Death and Survival | apoptosis of lung cancer cell lines | 5.80E-06 | ↓ | CAMP, EREG, G0S2, HSPA5, MCL1, RASD1, SERPINF1, TNFSF10 |
apoptosis of tumor cell lines | 2.08E-05 | ↓ | AR, BCL2A1, CAMP, CAV1, COL18A1, CREM, CTSD, EREG, G0S2, HSPA5, IL18, MAOA, MCL1, NFKBIA, NR0B2, PLAU, RASD1, SERPINF1, TNFSF10, UCHL1 | |
cell death of lung cancer cell lines | 3.21E-06 | ↓ | CAMP, EREG, G0S2, HSPA5, MCL1, NFKBIA, RASD1, SERPINF1, TNFSF10 | |
cell death of tumor cell lines | 2.75E-05 | ↓ | AR, BCL2A1, BTG1, CAMP, CAV1, COL18A1, CREM, CTSD, EREG, FETUB, G0S2, HSPA5, IL18, MAOA, MCL1, NFKBIA, NR0B2, PLAU, PPAT, RASD1, SERP | |
cellular degradation | 3.77E-04 | ↓ | AR, CACNA1D, CAV1, CREM, CTSD, LYZ, UCHL1 | |
Cellular Assembly and Organization | formation of filaments | 1.36E-03 | ↑ | AR, CAV1, COL18A1, HSPA5, PTGDS, SERPINF1, TTR, TUBB |
Organismal Development | development of body axis | 1.99E-04 | ↑ | ANGPTL3, CCKAR, COL18A1, CREM, CTSD, DIO3, GPR34, HHEX, HSP90B1, INSIG1, LUM, MAOA, NFKBIA, PLAU, SERPINF1 |
Immune Cell Trafficking | activation of antigen presenting cells | 3.47E-04 | ↓ | CAMP, GJB1, HNF4A, HSP90B1, IL18, LECT2, SERPINF1, TNFSF10 |
Renal and Urological System Development | cell viability of kidney cell lines | 3.05E-04 | ↓ | CAV1, HSP90B1, HYOU1, NFKBIA |
Cardiovascular Disease | vascular lesion | 2.94E-07 | ↑ | ACAT2, CACNA1D, COL18A1, IL18, LPL, MGP, mir-221, NFKBIA, PLAU, TNFSF10 |