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Table 5 Predictable changes in biological functioning based on DEG analysis in low-RFI individuals

From: Combination analysis of genome-wide association and transcriptome sequencing of residual feed intake in quality chickens

Categories Functions annotation P-value Predicted Molecules
Cell Death and Survival apoptosis of lung cancer cell lines 5.80E-06 CAMP, EREG, G0S2, HSPA5, MCL1, RASD1, SERPINF1, TNFSF10
apoptosis of tumor cell lines 2.08E-05 AR, BCL2A1, CAMP, CAV1, COL18A1, CREM, CTSD, EREG, G0S2, HSPA5, IL18, MAOA, MCL1, NFKBIA, NR0B2, PLAU, RASD1, SERPINF1, TNFSF10, UCHL1
cell death of lung cancer cell lines 3.21E-06 CAMP, EREG, G0S2, HSPA5, MCL1, NFKBIA, RASD1, SERPINF1, TNFSF10
cell death of tumor cell lines 2.75E-05 AR, BCL2A1, BTG1, CAMP, CAV1, COL18A1, CREM, CTSD, EREG, FETUB, G0S2, HSPA5, IL18, MAOA, MCL1, NFKBIA, NR0B2, PLAU, PPAT, RASD1, SERP
cellular degradation 3.77E-04 AR, CACNA1D, CAV1, CREM, CTSD, LYZ, UCHL1
Cellular Assembly and Organization formation of filaments 1.36E-03 AR, CAV1, COL18A1, HSPA5, PTGDS, SERPINF1, TTR, TUBB
Organismal Development development of body axis 1.99E-04 ANGPTL3, CCKAR, COL18A1, CREM, CTSD, DIO3, GPR34, HHEX, HSP90B1, INSIG1, LUM, MAOA, NFKBIA, PLAU, SERPINF1
Immune Cell Trafficking activation of antigen presenting cells 3.47E-04 CAMP, GJB1, HNF4A, HSP90B1, IL18, LECT2, SERPINF1, TNFSF10
Renal and Urological System Development cell viability of kidney cell lines 3.05E-04 CAV1, HSP90B1, HYOU1, NFKBIA
Cardiovascular Disease vascular lesion 2.94E-07 ACAT2, CACNA1D, COL18A1, IL18, LPL, MGP, mir-221, NFKBIA, PLAU, TNFSF10