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Table 1 The 15 genomics regions associated with 207 tumor suppressor genes (TSGs) with frequent copy number losses (CNLs)

From: Concordance of copy number loss and down-regulation of tumor suppressor genes: a pan-cancer study

Cytoband p-value q-value # TSGs TSG list
3p21.3 5.98E-19 3.48E-16 14 CTDSPL, CYB561D2, LIMD1, MST1R, NPRL2, PTPN23, RASSF1, RBM5, RBM6, RHOA, SEMA3B, SEMA3F, TUSC2, ZMYND10
8p22 4.48E-09 9.78E-07 7 CCAR2, DLC1, LZTS1, MIR383, MTUS1, SOX7, ZDHHC2
11p15.5 5.05E-09 9.78E-07 10 CDKN1C, H19, MIR210, MIR483, NUP98, RNH1, SIRT3, TRIM3, TSPAN32, TSSC4
17p13.1 5.30E-08 7.71E-06 9 ALOX15B, BCL6B, GABARAP, MIR195, MIR497, TNK1, TP53, XAF1, ZBTB4
19p13.3 2.52E-06 2.93E-04 10 AMH, DAPK3, DIRAS1, FZR1, GADD45B, PLK5, SIRT6, STK11, TCF3, TNFSF9
8p21.3 3.45E-06 3.34E-04 5 DOK2, MIR320A, PIWIL2, PPP3CC, RHOBTB2
3p21.31 3.63E-05 3.01E-03 6 CDCP1, LTF, MIR1226, SETD2, SMARCC1, TDGF1
3p21.1 1.49E-04 1.02E-02 4 ACY1, CACNA2D3, MIR135A1, MIRLET7G
6q26 1.58E-04 1.02E-02 3 MAP3K4, IGF2R, PACRG
10q24-q25 2.09E-04 1.16E-02 2 CHUK, MXI1
8p21 2.19E-04 1.16E-02 3 BNIP3L, EXTL3, TNFRSF10A
17p13.3 2.40E-04 1.16E-02 5 ALOX15, MNT, MYBBP1A, PAFAH1B1, VPS53
22q13.31 2.62E-04 1.17E-02 4 FBLN1, MIRLET7B, MIRLET7A3, PPARA
9p21 7.46E-04 3.10E-02 3 CDKN2A, CDKN2B, MTAP
3p21 1.08E-03 4.19E-02 3 GNAT1, MST1, PBRM1
  1. q-values were calculated by Benjamini-Hochberg multiple testing correction of the raw p-values, which were calculated by the hypergeometric test