Table 2 Selected differentially expressed genes utilizing an equine specific microarray following administration of an escalating dosing regimen (0.8 μg/kg, BID × 3 days; 1.6 μg/kg, BID × 3 days; 2.4 μg/kg, BID × 3 days; 3.2 μg/kg, BID for 21 days) to 6 exercised Thoroughbred research horses. For microarray analysis, baseline (pre-dose) transcript levels were compared to transcript levels on day 28
Gene symbol | Gene name | Fold change | P value (FDR corrected) |
|---|---|---|---|
MYH2A | Myosin Heavy Chain 2A, skeletal muscle | −30.5 | <0.001 |
MYH7 | Myosin Heavy Chain 7, cardiac and skeletal | 1.39 | 0.002 |
MYH8 | Myosin Heavy Chain 8, skeletal muscle | 1.86 | 0.014 |
MYH9 | Myosin Heavy Chain 9, non-muscle | −2.60 | 0.001 |
MYH10 | Myosin Heavy Chain 10, non-muscle | −1.31 | 0.028 |
MYH11 | Myosin Heavy Chain 11, smooth muscle | −2.24 | 0.033 |
MYH15 | Myosin Heavy Chain 15 | 2.10 | <0.001 |
ADRB2 | Adrenoreceptor, beta 2 | −4.0 | 0.001 |
COL1A1 | Collagen, type 1, alpha 1 | −1.8 | 0.019 |
IL1A | Interleukin 1, alpha | 3.42 | <0.001 |
IL6 | Interleukin 6 | 3.38 | 0.002 |
IL31RA | Interleukin 31, receptor A | 2.77 | <0.001 |
DSC2 | Desmocollin 2 | 2.95 | 0.001 |
PMP22 | Peripheral myelin protein 22 | −2.5 | <0.001 |
PMPCA | Peptidase alpha | −2.64 | <0.001 |
KRTAP20-2 | Keratin associate protein 20-2 | 7.32 | <0.001 |