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Table 2 Selected differentially expressed genes utilizing an equine specific microarray following administration of an escalating dosing regimen (0.8 μg/kg, BID × 3 days; 1.6 μg/kg, BID × 3 days; 2.4 μg/kg, BID × 3 days; 3.2 μg/kg, BID for 21 days) to 6 exercised Thoroughbred research horses. For microarray analysis, baseline (pre-dose) transcript levels were compared to transcript levels on day 28

From: Differential expression of skeletal muscle genes following administration of clenbuterol to exercised horses

Gene symbol Gene name Fold change P value (FDR corrected)
MYH2A Myosin Heavy Chain 2A, skeletal muscle −30.5 <0.001
MYH7 Myosin Heavy Chain 7, cardiac and skeletal 1.39 0.002
MYH8 Myosin Heavy Chain 8, skeletal muscle 1.86 0.014
MYH9 Myosin Heavy Chain 9, non-muscle −2.60 0.001
MYH10 Myosin Heavy Chain 10, non-muscle −1.31 0.028
MYH11 Myosin Heavy Chain 11, smooth muscle −2.24 0.033
MYH15 Myosin Heavy Chain 15 2.10 <0.001
ADRB2 Adrenoreceptor, beta 2 −4.0 0.001
COL1A1 Collagen, type 1, alpha 1 −1.8 0.019
IL1A Interleukin 1, alpha 3.42 <0.001
IL6 Interleukin 6 3.38 0.002
IL31RA Interleukin 31, receptor A 2.77 <0.001
DSC2 Desmocollin 2 2.95 0.001
PMP22 Peripheral myelin protein 22 −2.5 <0.001
PMPCA Peptidase alpha −2.64 <0.001
KRTAP20-2 Keratin associate protein 20-2 7.32 <0.001