Fig. 6From: The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dogHistopathologic assessment of the pancreases of rats treated with 15 and 50ug/kg of caerulein. Histopathologic assessment of organs was performed at 8, 24 and 48Â h with dose, time and animal number indicated on the x-axis and the grade of injury indicated on the y-axis (grey-blue indicates slight injury, green indicates moderate injury, blue indicates minimal injury and pink indicates marked injury). Rat pancreases displayed minimal and slight pancreatic necrosis in 4 vehicle treated rats at 24 and 48Â h while dose responsive increases in the severity of necrosis was noted in the 15 and 50ug/kg treatred rats at 8, 24 and 48Â hBack to article page