Fig. 2

Comparison of functional miRNA expression between different cell lines. miRNA reporter expression shown in Fig. 1 was compared between the four EBV⁺ cell lines and the EBV⁻ cell line HK1-miR-BART (expressing the whole BART cluster except BART2). Every dot represents the relative reporter expression of a specific miRNA normalized to the control reporter. Since the BHRF1 miRNAs and BART2-3p and 5p were not included in the lentiviral vector introduced in the HK1 cell line, these miRNAs were not expressed in this cell line and are therefore not depicted in the HK1 plots. In AKBM the miRNA reporters were barely downregulated, making a comparison with the other cell lines less informative. These plots are shown in Additional file 3. The dashed line indicates the diagonal (no difference in relative reporter expression between both cell lines)