Table 3 Pathways of interest significantly represented in the blood transcriptome
Pathway | Pathway # | #T/#G | p-value |
|---|---|---|---|
Protein processing in endoplasmic reticulum | K4141 | 136/149 | 5.58E-17 |
Metabolic pathways | K1100 | 663/916 | 8.49E-17 |
mRNA processing | WP411 | 108/116 | 1.51E-14 |
Lysosome | K4142 | 102/111 | 2.62E-13 |
Ubiquitin mediated proteolysis | K4120 | 114/128 | 1.59E-12 |
Ribosome | K3010 | 68/70 | 2.93E-12 |
Electron Transport Chain | WP111 | 67/69 | 1.08E-11 |
Apoptosis | K4210 | 70/75 | 4.72E-10 |
Oxidative phosphorylation | K190 | 82/92 | 3.15E-09 |
B cell receptor signaling pathway | K4662 | 63/68 | 7.37E-09 |
T cell receptor signaling pathway | K4660 | 85/99 | 7.68E-08 |
Neurotrophin signaling pathway | K4722 | 97/116 | 1.11E-07 |
Toll-like receptor signaling pathway | K4620 | 66/75 | 3.91E-07 |
Natural killer cell mediated cytotoxicity | K4650 | 71/83 | 1.41E-06 |
Translation Factors | WP107 | 41/43 | 2.56E-06 |
Androgen receptor signaling pathway | WP138 | 73/86 | 6.13E-06 |
Antigen processing and presentation | K4612 | 34/36 | 1.45E-05 |
DNA replication | K3030 | 31/33 | 5.79E-05 |
MAPK signaling pathway | WP382 | 117/153 | 8.20E-05 |
NOD-like receptor signaling pathway | K4621 | 42/48 | 1.00E-04 |
Proteasome | K3050 | 38/43 | 2.00E-04 |
Phagosome | K4145 | 84/109 | 3.00E-04 |
RIG-I-like receptor signaling pathway | K4622 | 45/53 | 3.00E-04 |
Citrate cycle (TCA cycle) | K20 | 26/28 | 4.00E-04 |
Endocytosis | K4144 | 127/175 | 5.00E-04 |
Protein export | K3060 | 21/22 | 5.00E-04 |
Insulin signaling pathway | K4910 | 92/123 | 8.00E-04 |
Peroxisome | K4146 | 56/72 | 2.30E-03 |
Primary immunodeficiency | K5340 | 28/33 | 4.60E-03 |
IL-7 signaling pathway | WP205 | 22/24 | 5.60E-03 |
Chemokine signaling pathway | K4062 | 105/152 | 1.82E-02 |