Fig. 6

Tubulin and cilia-associated genes in regeneration. A schematic depicting the possible involvement of tubulin and cilia enriched gene products in aboral regeneration. The axoneme of the cilia together with the basal body and its associated BBSome complex (see text) are illustrated. The graphs of representative early aboral enriched genes that are known to reside in cilia are shown: one of the two Tubulin3α whose products are part of the microtubules; IFT80, which is part of the dynein-driven IFT protein complex; and BBS5, which is a member of the BBSome coat complex that is linked to the basal body of the cilia. The inset in the Tubulin3α panel depicts the expression level in different body parts of intact polyps: T, tentacles; O, oral ring and pharynx; M, mesenteries and P, physa. IFT, intra-flagellar transport; BBSome, Bardet-Biedl Syndrome protein complex