From: In vivo Ebola virus infection leads to a strong innate response in circulating immune cells
Study | Ref. | Tissue | Group | Platform | Num. animals | Num. samples | Timepoints (samples/timepoint) |
---|---|---|---|---|---|---|---|
Macaque model of intramuscular exposure to Ebola virus | [17] | PBMC | rVSV/EBOV-GP (vaccinated) | RNAseq | 9 | 9 | 0, 4, 7 dpi (n = 3) |
rVSV/MARV-GP (Ebola-naïve) | RNAseq | 9 | 9 | 0, 4, 7 dpi (n = 3) | |||
Macaque model of aerosol exposure to Ebola virus | [19] | PBMC | EBOV | RNAseq | 8 | 12 | 0 (n = 4), 1 (n = 2), 3 (n = 2), 6 (n = 2), 8 (n = 2) dpi |
Microarray | 14a | 36a | 0 (n = 18), 1 (n = 2), 3 (n = 2), 4 (n = 4), 5 (n = 4), 6 (n = 2), 7 (n = 2), 8 (n = 2) dpi | ||||
Spleen | RNAseq | 19 | 19 | 0 (n = 2), 1 (n = 3), 3 (n = 3), 4 (n = 2), 5 (n = 2), 6 (n = 2), 7 (n = 3), 8 (n = 2) dpi | |||
Adrenal gland | 12 | 12 | 1 (n = 2), 3 (n = 1), 4 (n = 2), 6 (n = 1), 7 (n = 3), 8 (n = 2) dpi | ||||
Lymph node | 6 | 6 | 0, 1, 3, 4, 5, 6 dpi (n = 1) | ||||
Brain | 10 | 10 | 1, 3, 4, 6, 7 (n = 2) | ||||
Liver | 4 | 4 | 0, 3, 5, 8 dpi (n = 1) | ||||
Pancreas | 3 | 3 | 0, 4, 8 dpi (n = 1) | ||||
Mouse model of exposure to Ebola virus | [9] | Spleen | WT-EBOV | Microarray | 15 | 15 | 0 (n = 2), 12 (n = 4), 24 (n = 3), 36 (n = 3), 48 (n = 3) hpi |
MA-EBOV | 14 | 14 | 0 (n = 2), 12 (n = 3), 24 (n = 3), 36 (n = 3), 48 (n = 3) hpi | ||||
Macaque model of aerosol exposure to Lassa and Marburg virus | [24] | PBMC | LASV | RNAseq | 7 | 12 | 0 (n = 4), 3 (n = 4), 6 (n = 2), 10 (n = 2) dpi |
 | 9 | 12 | 0, 3, 5, 9 dpi (n = 3) |