Terma | Genes | Enrichment | Adj p-value |
---|---|---|---|
Up-regulated (53/101 unique genes) | |||
 Centralspindlin complex | Racgap1, Kif23 | 72.4 | 2.4e-03 |
 Chromosome passenger complex | Cdca8, Birc5 | 48.3 | 5.1e-03 |
 MCM complexb | Mcm2, Mcm3, Mcm6 | 31.1 | 1.5e-03 |
 Chromatin assembly | Mcm2, Cenpa, Hmga1, Hmga2, Chaf1b, H2afz | 15.1 | 2.0e-04 |
 Chromosome condensation | Ncapd2, Nusap1, Top2a, Hmga2, Ccnb1 | 17.3 | 5.0e-04 |
 Sister chromatid segregation | Ccnb1, Cdca8, Knstrn, Ncapd2, Nusap1, Top2a | 11.2 | 3.2e-04 |
 Kinetochore | Birc5, Ccnb1, Cenpa, Knstrn, Trp53bp1 | 9.9 | 1.5e-02 |
 Cytokinesis | Racgap1, Nusap1, Kif23, Birc5, Ckap2, Anln, Prc1 | 8.1 | 8.0e-04 |
 Steroid metabolic process | Lss, Hsd17b12, Fdft1, Msmo1, Ldlr, Mvd, Hmgcr | 6.1 | 1.3e-03 |
 Nucleotide metabolic process | Dhfr, Gapdh, Gmpr, Hmgcr, Pkm, Pnkp, Rrm2, Taldo1, Tk1, Tpi1 | 5.8 | 5.2e-04 |
 Histone binding | Chaf1b, Hist1h4n, Mcm2, Ncapd2, Trp53bp1,Uhrf1 | 5.5 | 2.7e-02 |
 Spindle | Racgap1, Kif23, Cdca8, Birc5,Dlgap5, Ccnb1, Knstrn1, Nusap1, Prc1 | 5.3 | 1.5e-03 |
 Extracellular matrix | Itgb1, Gpc3, Fbln2, Fn1, Hsd17b12, Anxa2, Mmp2, Pkm, Rpsa | 4.6 | 3.3e-03 |
 Mitotic nuclear division | Anln, Birc5, Ccna2, Ccnb1, Ccnb2, Cdc20, Cdca8, Hmga2, Kif23, Knstrn, Ncapd2, Nusap1, Racgap1, Triobp | 4.3 | 5.0e-04 |
 Histone deacetylase binding | Cdc20, Hsp90ab1,Top2a | 4.2 | 2.4e-02 |
 Centrosome | Ccnb1, Kif23, Tcp1, Cdc20, Krt18, Ccnb2, Cdca8, Birc5, Dlgap5, Ckap2, Mcm3, Tacc3 | 4.1 | 1.0e-03 |
 Negative regulation of Wnt signaling | Gpc3, Hmga2, Nxn | 4.0 | 3.4e-02 |
Down-regulated (35/80) | |||
 mRNA processingc | Ddx3x, Ttc14, Clk4, Rps24, Eif4a2, Sfpq, Matr3, Clk1, Rbms1, Srsf11, Zfml | 17.1 | 5.0e-11 |
 Unfolded & misfolded protein binding | Hsp90b1, Hspa5, Dnaja2, Dnajc3 | 10.6 | 3.2e-02 |
 Histone acetyl transferase activity | Crebbp, Ogt | 9.1 | 2.1e-02 |
 Cysteine-type peptidase activity | Ctsb, Ctsh, Otud7b, Senp6, Usp3 | 8.7 | 1.2e-02 |
 Response to ER stress | Dnajc3, Hsp90b1, Hspa5, Itpr1, Pdia3, Pdia4 | 8.3 | 7.5e-03 |
 Nuclear body | Neat1, Sfpq, Malat1, Atrx, Crebbp | 7.6 | 3.5e-02 |
 Regulation of chromosome organization | Atrx, Ogt, Paxbp1, Pten, Senp6, Sfpq | 5.5 | 1.3e-02 |
 Wnt signaling pathway | Ddx3x, Ndrg2, Pten | 3.1 | 4.7e-02 |
 Apoptotic signaling in response to DNA damage | Cdip1, Nupr1 | 2.8 | 3.3e-02 |
 Tumor suppressiond | Crebbp, Ddx3x, Eef1a1, Pten, Hsp90b1, Arhgef12 Nupr1, Pdcd4, Ndrg2 | 2.9 | 1.3e-03 |