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Fig. 3 | BMC Genomics

Fig. 3

From: The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets

Fig. 3

Determination of co-expressed gene modules related to PB and abiotic stresses. Modules were identified using hierarchical clustering followed by dynamic tree cutting algorithm in WGCNA. Each co-expression module was assigned to a unique color (Panel a). The number of genes that grouped into each module ranged from 28 (module darkgrey) to 988 (module turquoise) (Panel b). Modules were related to our experimental conditions, and we could detect modules significantly correlated to polymyxin B, low pH and high iron (marked in bold in Panel c). The membership of each gene to its module and its significance to the experimental condition is plotted for selected modules in Panel d. These genes can be regarded as key drivers in these modules

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