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Table 1 Comparison of additive models with and without non-linear interactions between candidate gene pairs in CATHGEN

From: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles

 

Additive Model

Interactive Model

Number of pairs

1120

677

Number of candidate genes

20

38

  1. Number of significant pairs defined as having one or both RNAs associated with MI (p < 0.05) and number candidate genes forming those pairs. Shown for an additive versus interactive model. Additive model: MI as explained by main effects of candidate genes (logit(MI) ~ RNA1 + RNA2 + additional covariates). Interactive model: MI as explained by main effects of candidate genes and an interaction term (logit(MI) ~ RNA1 + RNA2 + RNA1*RNA2 + additional covariates)