Table 2 The power comparison of SKAT, SKAT-O, and AP-SKAT aimed at testing the association between randomly selected 5 kb regions and continuous traits under the effect size = 0.8
From: AP-SKAT: highly-efficient genome-wide rare variant association test
SKAT | SKAT-O | AP-SKAT | |||||||
|---|---|---|---|---|---|---|---|---|---|
|  | 10−2 | 10−3 | 10−4 | 10−2 | 10−3 | 10−4 | 10−2 | 10−3 | 10−4 |
250 | 3.83E-2 | 6.96E-3 | 1.23E-3 | 3.85E-2 | 6.96E-3 | 1.25E-3 | 3.91E-2 | 7.02E-3 | 1.36E-3 |
500 | 8.60E-2 | 2.22E-2 | 5.41E-3 | 8.72E-2 | 2.23E-2 | 5.47E-3 | 8.86E-2 | 2.23E-2 | 5.66E-3 |
750 | 1.52E-1 | 4.83E-2 | 1.45E-2 | 1.52E-1 | 4.84E-2 | 1.46E-2 | 1.55E-1 | 4.88E-2 | 1.52E-2 |
1000 | 2.21E-1 | 8.19E-2 | 2.96E-2 | 2.24E-1 | 8.50E-2 | 2.99E-2 | 2.26E-1 | 8.53E-2 | 3.02E-2 |
1250 | 2.98E-1 | 1.30E-1 | 5.10E-2 | 2.99E-1 | 1.31E-1 | 5.29E-2 | 3.01E-1 | 1.32E-1 | 5.37E-2 |
1500 | 3.70E-1 | 1.91E-1 | 8.11E-2 | 3.74E-1 | 1.93E-1 | 8.28E-2 | 3.75E-1 | 1.90E-1 | 8.49E-2 |