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Table 2 The power comparison of SKAT, SKAT-O, and AP-SKAT aimed at testing the association between randomly selected 5 kb regions and continuous traits under the effect size = 0.8

From: AP-SKAT: highly-efficient genome-wide rare variant association test

SKAT SKAT-O AP-SKAT
  10−2 10−3 10−4 10−2 10−3 10−4 10−2 10−3 10−4
250 3.83E-2 6.96E-3 1.23E-3 3.85E-2 6.96E-3 1.25E-3 3.91E-2 7.02E-3 1.36E-3
500 8.60E-2 2.22E-2 5.41E-3 8.72E-2 2.23E-2 5.47E-3 8.86E-2 2.23E-2 5.66E-3
750 1.52E-1 4.83E-2 1.45E-2 1.52E-1 4.84E-2 1.46E-2 1.55E-1 4.88E-2 1.52E-2
1000 2.21E-1 8.19E-2 2.96E-2 2.24E-1 8.50E-2 2.99E-2 2.26E-1 8.53E-2 3.02E-2
1250 2.98E-1 1.30E-1 5.10E-2 2.99E-1 1.31E-1 5.29E-2 3.01E-1 1.32E-1 5.37E-2
1500 3.70E-1 1.91E-1 8.11E-2 3.74E-1 1.93E-1 8.28E-2 3.75E-1 1.90E-1 8.49E-2