Fig. 4From: Acquisition and loss of virulence-associated factors during genome evolution and speciation in three clades of Bordetella speciesGenome comparison of B. holmesii and B. hinzii. Protein similarity (TBLASTX) between the genomes as red lines (direct matches) and blue lines (inverted matches). The gray bars represent the forward and reverse DNA strands, black triangles denote IS elements (ISEs). Many chromosomal break points are flanked by ISEs suggesting genome reduction via ISEsBack to article page