Differential gene expression in Varroa jacobsoni mites following a host shift to European honey bees ( Apis mellifera )

Table 6 Most specific GO in mite genes that are up-regulated in the A. mellifera host, cluster 2 and 3

GO-ID	Term	Category	P-Value	Am-Up seq. count^a	Ref seq. count^b
Cluster 2 (208 CDEG)
GO:0005746	mitochondrial respiratory chain	C	0.000198	4	61
GO:0016272	prefoldin complex	C	0.000182	2	6
GO:0003006	developmental process involved in reproduction	P	0.000016	24	1332
GO:0010029	regulation of seed germination	P	0.000233	2	7
GO:0007281	germ cell development	P	0.000119	14	665
GO:1990204	oxidoreductase complex	C	0.000855	5	85
GO:0061028	establishment of endothelial barrier	P	0.000476	3	16
GO:0005801	cis-Golgi network	C	0.000169	3	26
GO:0048569	post-embryonic organ development	P	0.000254	11	489
GO:0048610	cellular process involved in reproduction	P	0.000267	18	1065
Cluster 3 (56 CDEG)
GO:0097136	Bcl-2 family protein complex	C	0.000016	1	1
GO:0051400	BH domain binding	F	0.000057	1	6
GO:0001783	B cell apoptotic process	P	0.000089	1	10
GO:0004301	epoxide hydrolase activity	F	0.000033	1	3
GO:0004463	leukotriene-A4 hydrolase activity	F	0.000041	1	4
GO:0060509	Type I pneumocyte differentiation	P	0.000049	1	5
GO:0019370	leukotriene biosynthetic process	P	0.000057	1	6
GO:0016803	ether hydrolase activity	F	0.000073	1	8
GO:0016801	hydrolase activity, acting on ether bonds	F	0.000097	1	11
GO:0006691	leukotriene metabolic process	P	0.000138	1	16

Fisher’s exact test showing enriched GO terms in mite genes that are up-regulated in A. mellifera host (cluster 2 and 3). For a complete list and gene ID see (Additional file 7: Table S7; Additional file 8: Table S9). ^a208 and 56 genes in each test set, respectively. ^bnumber of times the GO was identified in reference set of 37,661 genes