Mining kidney toxicogenomic data by using gene co-expression modules

BMC Genomics

Table 5 Gene Ontology (GO)-biological process (BP) term enrichment for acute kidney injury (AKI)-relevant gene set^a

Pathway	log₁₀ p-value
Immune response	−5.01
Defense response	−4.47
Response to virus	−4.02
Immune system process	−3.57
Response to external stimulus	−3.57
Response to stimulus	−3.57
Response to biotic stimulus	−3.50
Multi-organism process	−3.35
Response to cytokine	−3.32
Regulation of viral process	−3.17
Response to interferon-beta	−2.89
Response to organic substance	−2.79
Viral genome replication	−2.74
Single-organism process	−2.74
Response to chemical	−2.67
Regulation of symbiosis	−2.48
Cellular response to interferon-beta	−2.41
Response to interferon-alpha	−2.39
Glutathione metabolic process	−2.89
Nucleobase-containing small molecule metabolic process	−2.08
Positive regulation of cell-killing	−2.43
Cell-killing	−2.12

^aEnriched GO-BP terms were clustered and summarized by using REVIGO webserver [45]

ISSN: 1471-2164