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Table 3 Somatic mutations identified using the two panels

From: Comparison between two amplicon-based sequencing panels of different scales in the detection of somatic mutations associated with gastric cancer

Case Specimen Characteristics Gene Mutation Selective hotspot panel, allelic fraction Comprehensive panel, allelic fraction
Case 1 ESD Early MUC6 F1843S Not included 28 %
MUC6 S1531P Not included 23 %
PKHD1 F83S Not included 11 %
Case 2 ESD Early ZIC4 R107H Not included 21 %
RASA1 K825X Not included 21 %
Case 3 ESD Early MACF1 L2900F Not included 11 %
Case 4 ESD Early APC C207X Not included 34 %
APC Q1447X 35 % 31 %
MUC6 A1637Q Not included 16 %
SYNE1 D5070G Not included 13 %
PKHD1 Q3467K Not included 12 %
MUC6 L1836H Not included 10 %
Case 5 ESD Early SYNE1 G474R Not included 83 %
TP53 G266V 83 % 65 %
PKHD1 R723C Not included 32 %
FAM46D S69C Not included 16 %
Case 6 ESD Early MUC6 T2041M Not included 33 %
SMAD2 A278P Not included 17 %
MACF1 R3680K Not included 14 %
Case 7 ESD Early TP53 D148fs 67 % 61 %
Case 8 ESD Early APC L1564X 42 % 59 %
SYNE1 D903Y Not included 43 %
APC S940X Not included 42 %
TMPRSS2 L141V Not included 40 %
AKAP13 A2256V Not included 28 %
MUC6 T2041M Not included 25 %
MUC6 P1571T Not included 21 %
Case 9 ESD Early APC Q1237fs Not included 38 %
Case 10 ESD Early TP53 H193Y 63 % 52 %
APC S1068X Not included 42 %
SMAD4 G477X Not included 35 %
KRAS G13D 38 % 33 %
RHOA M1V 13 % 14 %
APC Q1517fs 5 % 14 %
Case 11 ESD Early ELF3 D220N Not included 42 %
SYNE1 K874N Not included 40 %
SMAD4 R497H 28 % 39 %
FAT4 K225E Not included 35 %
KMT2C Y987H Not included 33 %
ERBB2 R897Q Not included 32 %
SYNE1 R7753H Not included 32 %
MET N381fs 19 % 13 %
Case 12 ESD Early APC R876X 38 % 38 %
MUC6 T2041M Not included 28 %
Case 13_site1a ESD Early TP53 R209fs 70 % 67 %
ARHGAP5 L297X Not included 31 %
PKHD1 I3786M Not included 12 %
Case 13_site2a ESD Early TP53 E258D Not included 71 %
MACF1 D968A Not included 51 %
Case 14 ESD Early - - Not detected Not detected
Case 15 ESD Early SYNE1 R6836C Not included 51 %
ACVR2A R202fs Not included 39 %
MUC6 S2378fs Not included 38 %
DLC1 E854K Not included 17 %
Case 16 ESD Early ARID1A K1072fs 43 % 51 %
RASA1 R512X 44 % 41 %
TP53 G154S 35 % 32 %
RASA1 D380E 18 % 19 %
MUC6 P1724S Not included 15 %
ARHGAP5 L259S Not included 10 %
Case 17 ESD Early CTNNB1 S45F 40 % 32 %
Case 18 ESD Early TP53 N200fs 3 % 16 %
Case 19 Biopsy Early TP53 R175H 15 % 6 %
APC E262X Not included 12 %
Case 20 Biopsy Advanced TGFBR2 S94R Not included 28 %
CDH1 Splice site Not included 28 %
MACF1 G5253E Not included 19 %
TP53 R248Q 17 % 16 %
DNAH7 Y2563N Not included 13 %
DLC1 W10L Not included 13 %
CDH1 Splice site (c.1009-2A>C) 13 % 8 %
  1. aCase 13 had two tumors