Fig. 1

Seven regions demonstrate regulatory activity in Schwann cells. Each of the 57 genomic segments containing prioritized SOX10 consensus sequences was cloned upstream of a luciferase reporter gene and tested for enhancer activity in cultured Schwann (S16) cells. Luciferase data are expressed relative to a control vector that does not harbor a genomic insert (‘Empty’). Regions that display a greater than 2.5-fold increase (red line) in luciferase activity are indicated in red text and by an arrow. Error bars indicate standard deviations