Fig. 3

SOX10 is required for the regulatory activities of SOX10-CCS-13, SOX10-CCS-19 and SOX10-CCS-51. a Luciferase reporter gene constructs harboring SOX10-CCS-13, SOX10-CCS-19 or SOX10-CCS-51 were transfected into mouse motor neurons (MN1) with or without a construct to express wild-type SOX10. The luciferase activity associated with each construct in the presence of SOX10 is expressed relative to that of the construct in the absence of SOX10. b Luciferase reporter gene constructs harboring SOX10-CCS-13, SOX10-CCS-19 or SOX10-CCS-51 were transfected into rat Schwann (S16) cells with or without a construct to express dominant-negative (E189X) SOX10. The luciferase activity associated with each construct in the presence of E189X SOX10 is expressed relative to that of the construct in the absence of E189X SOX10. Error bars indicate standard deviations in both panels