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Table 3 Mean and median distances between PQSs and recombination breakpoints in the P. falciparum 3D7 genome

From: Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs

Breakpoint type Number Mean distance from PQS (kb) Mean distance from PQS in null data (kb) Median distance from PQS (kb) Median distance from PQS in null data (kb) PQS association (median outside C.I.)
All 173 132.7 301 (Equal) 16.4 180.4 (Equal) Y
   193.8 (Unequal) C.I. 11.1–24.3 130.5 (Unequal) Y
All translocations 99 163.6 300.7 (Equal) 13.5 180.1 (Equal) Y
   193.4 (Unequal) C.I. 5.9–53.9 130.4 (Unequal) Y
Subtelomeric translocations only 65 109.5 300.1 (Equal) 4.8 180.6 (Equal) Y
   208.8 (Unequal) C.I. 3.5–8.9 129.7 (Unequal) Y
All var coding translocations 70 156.6 301.1 (Equal) 14.7 180.6 (Equal) Y
   181.7 (Unequal) C.I. 4.1–18.5 125.7 (Unequal) Y
Indels 74 91.4 300.9 (Equal) 20 179.9 (Equal) Y
   193.4 (Unequal) C.I. 11.3–28.4 130.3 (Unequal) Y
Var-coding events in progeny of 3D7/HB3 cross 24 56.2 300.1 (Equal) 2.9 180.7 (Equal) Y
   141.1 (Unequal) C.I. 2.5–11.3 98.8 (Unequal) Y
Analysis restricted to subtelomeres 119 91.3 133.5 (Equal) 9.1 22.8 (Equal) Y
   122.1 (Unequal) C.I. 6.3–15.4 18.8 (Unequal) Y
  1. Mean and median PQS-to-breakpoint distances are shown for each actual dataset and for two simulated null datasets: breakpoints distributed equally across the genome (equal), or breakpoints distributed according to the number actually observed per chromosome (unequal). The significance of the difference between each actual and null dataset is assessed by calculating a 95 % confidence interval (C.I.) around the sample median: a significant association is noted if the median of the null dataset is outside this confidence interval