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Fig. 3 | BMC Genomics

Fig. 3

From: Dwarfism with joint laxity in Friesian horses is associated with a splice site mutation in B4GALT7

Fig. 3

Conservation of B4GALT7. a Alignment of the N-terminal amino acid sequence of xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 of horse with that of several mammals, an amphibian and a fish. The protein sequences are derived from the reference cDNAs listed below. b Alignment of the splice donor site of exon 1 of B4GALT7 of horse with that of other vertebrate species. The exon DNA sequence is in upper case and that of the intron is in lower case. The residues in a and b that are mutated in Friesian horse dwarfs are underlined. Residues that are identical to those in horse are indicated by a dot; gaps that are introduced to optimize the alignment are indicated by a dash. The exon 1/intron 1 splice junctions are derived from the respective reference genomes and based on the following cDNA reference sequences. Horse (Equus caballus): XM_014730464; human: NM_007255; cow (Bos taurus): NM_001075321; pig (Sus scrofa): NM_001168422; rhinoceros (Ceratotherium simum): XM_010145472; rat (Rattus norvegicus): NM_001031661; bat (Eptesicus fuscus): XM_008143179; Dolphin (Tursiops truncatus): XM_004313659; frog [Xenopus (Silurana) tropicalis]: (NM_001126545); zebrafish (Danio rerio): NM_001003417

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