Prepartum body condition score and plane of nutrition affect the hepatic transcriptome during the transition period in grazing dairy cows

Table 3 Upstream differentially expressed transcription regulators and their target genes with fold change (FC) ≥ |3|

Transcription regulator	FC	Target genes and responses within the specific comparison
B4F125 vs B4F75
SIM1	−1.980	↑AOX1, ↑CBFB, ↓CD86, ↓GPX3, ↓PKIB, ↑STRN, ↓THEG
SOX2	−1.766	↑ALB, ↓ANGPT1, ↑APCDD1, ↑BCL9L, ↓CST6, ↓CXCR4, ↓FABP7, ↓MEIS1
MYOD1	−1.641	↓ACHE, ↓ATP7A, ↓CHRNG, ↓DAG1, ↓RBM38, ↓RYR1, ↑SP1
ERG	−1.552	↓CXCR4, ↓EZH2, ↑FMNL2, ↓HDAC6, ↓ITGA6, ↑ PTPN4
LHX1	−1.505	↓SIM1, ↑SOSTDC1, ↓TMIGD1, ↑ZKSCAN1
B5F125 vs B5F75
CUX1	−2.035	↓ECT2, ↑WNT6

ISSN: 1471-2164