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Table 5 Differentially expressed precursor miRNAs including Gms assigned as miRNA by Gencode with highest FC in kidney samples of the Ins2 Akita mice

From: Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq

A

B

Gene

Fold change

Gene

DvC

TvD

Mir1247

−86.22

Gm24083

43.15

−45.45

Gm24083

43.15

Gm25953

34.53

−36.37

Mir142b

−42.04

Mir1905

29.52

−5.19

Gm25953

34.53

Gm25535

−28.56

23.41

Mir1905

29.52

Gm27903

−26.25

11.75

Gm25535

−28.56

Mir196a‐1

22.61

−2.35

Gm27903

−26.25

Gm25738

−17.06

10.57

Gm23251

22.85

Gm25872

−16.27

23.35

Mir196a‐1

22.61

Gm28010

15.43

−3.08

Mir27a

20.80

Mir6991

14.82

−2.65

Mirlet7b

18.64

Mir6364

−12.80

8.06

Gm25738

−17.06

Gm27684

12.51

−1.86

Mir6386

16.74

Mir328

−11.78

8.56

Gm25872

−16.27

Mir1898

−9.23

9.49

Gm28010

15.43

Gm25361

−8.57

10.18

Mir6991

14.82

Gm23134

−6.45

1.80

Mir6981

13.64

Mir7036

−5.33

16.87

Mir6364

−12.80

Mir7001

−4.92

4.78

Gm27684

12.51

Mir3098

4.61

−3.51

Gm24515

11.93

Gm27768

−3.70

4.45

Mir328

−11.78

Gm25233

−3.70

4.45

Gm25297

11.09

Gm22734

−3.70

4.45

Mir1898

−9.23

Gm26043

2.96

−8.34

Gm25361

−8.57

Gm22721

−2.76

2.17

Gm27920

7.86

Gm25640

−2.43

6.59

Gm27512

7.53

Mir6363

−2.08

2.27

Gm28033

7.13

Gm25190

−1.93

2.33

Gm23134

−6.45

Mir27b

−1.84

2.01

Gm23268

−5.97

Mir3082

−1.66

1.57

  1. A. miRNAs regulated by diabetes with FC > =(+/-)5.97 (q < 0.05) relative to control.Genes are listed by highest numerical FC values (positive or negative), B. miRNAs with expression levels altered by diabetes that were reversed by P78 treatment. Genes are listed by highest numerical FC values (FC > =+/-1.66, q < 0.05) in DvC (first column) and the relative regulation values of these same genes after treatment (TvD) given in the second column