Fig. 2

Interactome evaluation indices. a Three indices for quantitative evaluation of each interaction. Each index is calculated for two signal directions (C-S direction: cancer ligand to stromal receptor, and S-C direction: stromal ligand to cancer receptor). b Visualization of the evaluation indices in C-S direction. X-axis represents cancer cell-ligand dependency and y-axis represents stromal receptor dependency, and positions of interaction indicate the role of the interaction in cancer-stromal relationships, and the size of circle (proportional to log of signal strength) indicates the strength of interaction. c Visualization of the evaluation indices in S-C direction, which is the counterpart of C-S direction