Fig. 3

Relationships between interactome profiles and desmoplastic reaction in the PDAC samples. a The number of mutually dependent interactions with strong signals in 8 PDAC samples. top left: signal strength >10 in C-S direction, top right: signal strength >10 in S-C direction, bottom left: signal strength >50 in C-S direction, bottom right: signal strength >50 in S-C direction. b Interactome profiles of PDAC samples obtained from mice models transplanted with Capan-1 (top), which has the strongest mutually dependent interactions, or MiaPaca-2 (bottom), which has the weakest mutually dependent interactions, transplanted mouse models. Left: C-S direction, right: S-C direction. c Hematoxylin and eosin (H&E) staining of formalin-fixed, paraffin-embedded PDAC tissue obtained from Capan-1 (top) and MiaPaca-2 (bottom) xenograft mouse models