Table 4 Mutually dependent interactions with strong signals in PDAC dataset
From: CASTIN: a system for comprehensive analysis of cancer-stromal interactome
ligand | receptor | direction | signal strengtha | possible relevance for cancer-stromal interactions |
|---|---|---|---|---|
SEMA3C | NRP1 | C-S | 101.5 | SEMA3C induces growth and migration of endothelial cells [29], suggesting its angiogenic role; NRP1 also causes desmoplastic reaction in cancer [30]. |
WNT7B | GPC3 | C-S | 50 | In hepatocellular carcinoma, GPC3 promotes cancer cell growth by Wnt signaling including WNT7B [53]. |
COL1A2 | CD44 | S-C | 753 | CD44 expressed in PDAC regulates its invasion [54]. |
COL1A1 | CD44 | S-C | 668.4 | CD44 expressed in PDAC regulates its invasion [54]. |
FN1 | ITGA3 | S-C | 496.6 | Not reported |
COL1A2 | ITGA2 | S-C | 348.4 | α2β1 integrin-mediated adhesion on type I collagen promotes the malignant phenotype in PDAC [32]. |
COL1A1 | ITGA2 | S-C | 341.1 | α2β1 integrin-mediated adhesion on type I collagen promotes the malignant phenotype in PDAC [32]. |
FN1 | ITGB6 | S-C | 180.8 | Promotes breast cancer invasion [55]. |
SEMA4D | PLXNB1 | S-C | 63.4 | Promotes cancer cell motility in PDAC [33]. |
SFRP1 | FZD6 | S-C | 62 | FZD6 overexpressed in several cancers [56]; SFRP1 is a Wnt antagonist. |
IGF1 | IGF1R | S-C | 54.5 | IGF1R induces PDAC growth and metastasis [57]. |