Fig. 7
Comparative analyses of mRNA transcriptomes among bat, human, pig and cow. a-b The numbers of up-regulated and down-regulated genes in bat, respectively. The results of the three separate comparisons were intersected (bat vs human, bat vs pig, bat vs cow). c-d The top 5 Gene Ontology enriched terms of up-regulated and down-regulated genes in bat, respectively. The enriched terms with Padj-value < 0.05 were considered statistically significant. e The heatmap of 491 differentially expressed genes between bat and other mammals. The raw expression counts were normalized using the Trimmed of M-value (TMM) method. The rows were clustered using Pearson correlation method (normal distribution, P > 0.05), while the columns were clustered using Spearman correlation method (non-normal distribution, P < 0.05). f-i The relative accumulative gene expressions under certain enriched GO terms across bat, human, pig and cow. The raw expression counts were normalized using Trimmed mean of M-value (TMM) method, and the average gene expressions from the libraries of the same species were calculated and further summed based on the enriched GO terms