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Table 3 The top 10 biological processes for cold-related miRNA target genes

From: MicroRNAs regulate gene plasticity during cold shock in zebrafish larvae

Biological Processes of P value*
Cold-induced miRNA target genes
 Regulation of transcription, DNA-dependent 3.30E-04
 Polyol metabolic process 3.40E-04
 Regulation of RNA metabolic process 5.20E-04
 Regulation of transcription 6.70E-04
 Regulation of small GTPase mediated signal transduction 1.10E-03
 Ion transport 1.10E-03
 Glycerol metabolic process 1.30E-03
 Alditol metabolic process 1.30E-03
 Organophosphate metabolic process 1.50E-03
 Metal ion transport 1.60E-03
Cold-repressed miRNA target genes
 Metal ion transport 1.60E-04
 Protein amino acid phosphorylation 3.60E-04
 Intracellular signaling cascade 7.60E-04
 Ion transport 8.50E-04
 Cation transport 1.80E-03
 Potassium ion transport 1.80E-03
 Regulation of small GTPase mediated signal transduction 1.80E-03
 Organophosphate metabolic process 3.10E-03
 Monovalent inorganic cation transport 3.60E-03
 Regulation of Ras protein signal transduction 4.70E-03
  1. *calculated by Fisher Exact which is adopted to measure the gene-enrichment in annotation biological process
  2. Target genes of 29 up- and 26 down-regulated known miRNAs were predicted by TargetScan (Additional file 5). The target genes were annotated by DAVID bioinformatics resources 6.7. The top 10 biological processes of the target genes and P values are shown