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Table 4 The top 10 KEGG pathways for cold-related miRNA target genes

From: MicroRNAs regulate gene plasticity during cold shock in zebrafish larvae

KEGG pathway of P value*
Cold-induced miRNA target genes
 Cysteine and methionine metabolism 0.0027
 ECM-receptor interaction 0.0035
 Fructose and mannose metabolism 0.005
 Biosynthesis of unsaturated fatty acids 0.011
 Glycerophospholipid metabolism 0.011
 Inositol phosphate metabolism 0.014
 Sphingolipid metabolism 0.022
 Melanogenesis 0.028
 GnRH signaling pathway 0.029
 Circadian rhythm 0.034
Cold-repressed miRNA target genes
 Chondroitin sulfate biosynthesis 0.00081
 Synthesis and degradation of ketone bodies 0.0092
 Phosphatidylinositol signaling system 0.017
 Sphingolipid metabolism 0.019
 Notch signaling pathway 0.023
 O-Glycan biosynthesis 0.025
 Lysosome 0.03
 Alanine, aspartate and glutamate metabolism 0.035
 Glycosphingolipid biosynthesis 0.036
 Biosynthesis of unsaturated fatty acids 0.038
  1. *calculated by Fisher Exact which is adopted to measure the gene-enrichment in annotation KEGG pathway
  2. Target genes of 29 up- and 26 down-regulated known miRNAs were predicted by TargetScan (Additional file 5). The targets genes were annotated by DAVID bioinformatics resources 6.7. The top 10 KEGG pathway of the target genes and P values are shown