MicroRNAs regulate gene plasticity during cold shock in zebrafish larvae

BMC Genomics

Table 4 The top 10 KEGG pathways for cold-related miRNA target genes

KEGG pathway of	P value*
Cold-induced miRNA target genes
Cysteine and methionine metabolism	0.0027
ECM-receptor interaction	0.0035
Fructose and mannose metabolism	0.005
Biosynthesis of unsaturated fatty acids	0.011
Glycerophospholipid metabolism	0.011
Inositol phosphate metabolism	0.014
Sphingolipid metabolism	0.022
Melanogenesis	0.028
GnRH signaling pathway	0.029
Circadian rhythm	0.034
Cold-repressed miRNA target genes
Chondroitin sulfate biosynthesis	0.00081
Synthesis and degradation of ketone bodies	0.0092
Phosphatidylinositol signaling system	0.017
Sphingolipid metabolism	0.019
Notch signaling pathway	0.023
O-Glycan biosynthesis	0.025
Lysosome	0.03
Alanine, aspartate and glutamate metabolism	0.035
Glycosphingolipid biosynthesis	0.036
Biosynthesis of unsaturated fatty acids	0.038

*calculated by Fisher Exact which is adopted to measure the gene-enrichment in annotation KEGG pathway
Target genes of 29 up- and 26 down-regulated known miRNAs were predicted by TargetScan (Additional file 5). The targets genes were annotated by DAVID bioinformatics resources 6.7. The top 10 KEGG pathway of the target genes and P values are shown

ISSN: 1471-2164