Fig. 2

Phylogenetic tree of HAGs in oomycetes. The maximum-likelihood tree was constructed with sequences of conserved domain AT_1 of HAGs. Bootstrap values (≥30%) are shown near the tree nodes. The predicted HAGs were attributed to three known families, Gcn5, Hpa2 and Elp3. The conserved domains of each family were highlighted by different colors. In oomycetes, the Gcn5 family protein (the branch colored red) is composed of AT_1 and Bromodomain. The Elp3 family (the branch colored blue) encodes an Elp3 domain at the N-terminal in addition to the AT_1 domain, while most Hpa2s have only the AT_1 domain. Reference species are highlighted in different colors. Pif, Phytophthora infestans; Pr, P. ramorum; Pso, P. sojae; Pca, P. capsici; Ppa, P. parasitica; Pcn, P. cinnamomi; Pyu, Pythium ultimum; Al, Albugo laibachii; Hpa, Hyaloperonospora parasitica; Spa, Saprolegnia parasitica; Hsa, Homo sapiens; Sce, Saccharomyces cerevisiae; Ath, Arabidopsis thaliana; Pti, Phaeodactylum tricornutum; Tps, Thalassiosira pseudonana; Tet, Tetrahymena thermophile; Gla, Giardia lamblia