Fig. 3
From: The Drosophila transcriptional network is structured by microbiota
Genes in nutrient signaling networks require microbiota for structured coexpression. Modules exhibiting microbiota-dependent structure included genes with key roles in the IIS/TOR/AMPK nutrient signaling network. Pairwise coexpression (Spearman's Rho) of genes in the IIS/TOR/AMPK network [38, 39] is presented, for genes in differentially coexpressed modules. FoxO was not clustered into a DC module, but is plotted in the figure since it is the major transcriptional output of IIS. Numbers in each cell represent correlation coefficients. The figure demonstrates that the microbiota affects the regulation of these networks at the level of structured gene coexpression