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Table 4 Association of COPS5 with mitochondrial pathways in normal oral tissues

From: Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components

 

GO and KEGG pathways

Found

Expected

p

μ

1

GO:0003954 ~ NADH dehydrogenase activity

28

4

1.1E-16

0.00184

2

GO:0006120 ~ mitochondrial electron transport

28

4

1.1E-16

0.00179

3

GO:0070469 ~ respiratory chain

42

6

1.1E-16

0.00323

4

GO:0042773 ~ ATP synthesis coupled electron transport

34

5

1.1E-16

0.00233

5

GO:0042775 ~ mitochondrial ATP synthesis coupled electron transport

34

5

1.1E-16

0.00233

6

GO:0005747 ~ mitochondrial respiratory chain complex I

27

4

1.1E-16

0.00179

7

GO:0030964 ~ NADH dehydrogenase complex

27

4

1.1E-16

0.00179

8

GO:0045271 ~ respiratory chain complex I

27

4

1.1E-16

0.00179

9

GO:0045333 ~ cellular respiration

50

8

1.1E-16

0.00437

10

GO:0044455 ~ mitochondrial membrane part

62

10

1.1E-16

0.00571

11

hsa00190 ~ oxidative phosphorylation

61

10

1.1E-16

0.00576

12

GO:0005746 ~ mitochondrial respiratory chain

36

6

1.1E-16

0.00278

13

GO:0006119 ~ oxidative phosphorylation

48

8

1.1E-16

0.00442

14

GO:0022904 ~ respiratory electron transport chain

35

6

1.1E-16

0.00273

15

GO:0016655 ~ oxidoreductase activity

28

5

1.1E-16

0.00213

16

GO:0022900 ~ electron transport chain

48

9

1.1E-16

0.00516

17

GO:0015980 ~ energy derivation by oxidation of organic compounds

57

11

1.1E-16

0.00670

18

GO:0000313 ~ organellar ribosome

24

5

1.1E-16

0.00238

19

GO:0005761 ~ mitochondrial ribosome

24

5

1.1E-16

0.00238

20

GO:0005743 ~ mitochondrial inner membrane

96

21

1.1E-16

0.01454

  1. Found: Number of genes in a particular GO or KEGG pathway found in the top 1000 r COPS5 list; Expected: number of expected genes to yield p < 0.05 appearing in 1000 genes based on the average appearance per gene (μ); μ values were calculated by the total appearance of individual pathways in the entire gene list of 20,154. P values were calculated using binomial distribution in R. Expected occurrences in a list of 1000 genes to provide p < 0.05 are listed