Table 1 Candidate SNP markers of aggressiveness as an adverse effect of medical treatments (these markers may change the TBP–promoter affinity)
Gene | dbSNP [12] or see [Reference] | 5′ flank | \( \frac{\mathbf{wt}}{mut} \) | 3′ flank | KD, nM | Z-score | Known diseases (observations) [Reference] or hypothetical ones in the case of the candidate SNP markers predicted by us in [this work] (see Methods: Additional file 2 : Figure S1) | [Ref] or [this work] | ||
|---|---|---|---|---|---|---|---|---|---|---|
\( \frac{\mathbf{wt}}{mut} \) | Δ | Z | α | |||||||
GH1 | rs11568827 | aggggccagg | \( \frac{\mathbf{g}}{-} \) | tataaaaagg | \( \frac{\mathbf{1.5}}{1.4} \) | = | 1 | - | Short stature (unknown TF-binding site damaged rather than TATA box) | [69] |
(hypothetically) low aggression of patients during growth hormone treatment (case review); short stature and aggressiveness co-exist in Smith-Magenis syndrome, Dubowitz syndrome, Floating-Harbor syndrome; and females with constitutional short stature are more aggressive than the ones with Turner syndrome; children and adolescents with hypopituitarism have short stature and show a tendency to avoid aggressiveness (case reviews) | ||||||||||
rs796237787 | gaaggggcca | \( \frac{\mathbf{g}}{-} \) | ggtataaaaa | \( \frac{\mathbf{1.5}}{1.4} \) | = | 1 | - | |||
rs768454929 | agggtataaa | \( \frac{\mathbf{a}}{c} \) | agggcccaca | \( \frac{\mathbf{1.5}}{2.6} \) | ↓ | 7 | 10−6 | |||
rs761695685 | gccagggtat | \( \frac{\mathbf{a}}{g} \) | aaaagggccc | \( \frac{\mathbf{1.5}}{5.8} \) | ↓ | 19 | 10−6 | |||
rs774326004 | ccagggtata | \( \frac{\mathbf{a}}{t} \) | aaagggccca | \( \frac{\mathbf{1.5}}{0.9} \) | ↑ | 7 | 10−6 | (hypothetically) higher aggression of a mentally unstable patient during growth hormone treatment so that lithium (Li) and other antiaggression medication may be required (a retrospective clinical case review) | [this work] [70] | |
rs777003420 | aaggggccag | \( \frac{\mathbf{g}}{t} \) | gtataaaaag | \( \frac{\mathbf{1.5}}{1.3} \) | ↑ | 3 | 0.05 | |||
IL1B | rs1143627 | ttttgaaagc | \( \frac{\mathbf{c}}{t} \) | ataaaaacag | \( \frac{\mathbf{5}}{2} \) | ↑ | 15 | 10−6 | Greater body fat; gastric cancer, hepatocellular carcinoma, non-small cell lung cancer, gastritis and gastric ulcer, Graves’ disease, major recurrent depression, and also, (hypothetically) higher aggressiveness in patients who receive cytokine immunotherapy (clinical retrospective review) as well as Graves’ disease and aggressiveness are consequences of regular hemodialysis | |
rs549858786 | tgaaagccat | \( \frac{\mathbf{a}}{t} \) | aaaacagcga | \( \frac{\mathbf{5}}{6} \) | ↓ | 8 | 10 −6 | (hypothetically) less aggressive traits in patients who receive cytokine immunotherapy or regular hemodialysis (clinical retrospective review) | [this work],[84] | |