Table 2 Candidate SNP markers of aggressiveness-related drug responses (these markers may significantly change the TBP–promoter affinity)
Gene | dbSNP [12] or see [Reference] | 5′ flank | \( \frac{\mathbf{wt}}{mut} \) | 3′ flank | KD, nM | Z-score | Known diseases (observations) [Reference] or hypothetical ones in the case of the candidate SNP markers predicted by us in [this work] (see Methods: Additional file 2 : Figure S1) | [Ref] or [this work] | ||
|---|---|---|---|---|---|---|---|---|---|---|
\( \frac{\mathbf{wt}}{mut} \) | Δ | Z | α | |||||||
SOD1 | rs7277748 | ggtctggcct | \( \frac{\mathbf{a}}{g} \) | taaagtagtc | \( \frac{\mathbf{7}}{2} \) | ↑ | 17 | 10−6 | Familial amyotrophic lateral sclerosis (ALS), and also, (hypothetically) aggressiveness is a memantine response in Alzheimer's disease on the basis of this drug’s success in the case of ALS; aggressiveness at late stages of either ALS or traumatic encephalopathy [clinically similar to ALS]; lesser male–male aggression (SOD1-deficient mouse males) | |
StAR | rs16887226 | cagccttcag | \( \frac{\mathbf{c}}{t} \) | gggggacatt | \( \frac{\mathbf{10}}{10} \) | = | 1 | - | Diabetic hypertension (unknown TF-binding site damaged, not TATA box) | [91] |
(hypothetically) lithium (Li) is a common drug against aggressiveness, hypertension, and diabetes (case reviews); old women on lipid-lowering medication become more aggressive, hypertensive, and diabetic; both diabetes and hypertension coexist with aggressiveness in a magnesium (Mg) deficiency, in intermittent explosive disorder, in Alzheimer's disease, in postmenopausal women with multiple medical problems in contrast to reduced aggressiveness in old men regardless of disease and lesser male aggression (a fish model on human behavior);as well as coexistence of aggressiveness, hypertension, and diabetes can elevate risk of nonfatal myocardial infarction; diet has long-term impact on aggressiveness, hypertension, and diabetes; aggressiveness, hypertension, and diabetes are risk factors of cerebrovascular disease, cerebral sclerosis; | ||||||||||
rs544850971 | tcagcggggg | \( \frac{\mathbf{a}}{g} \) | catttaagac | \( \frac{\mathbf{10}}{12} \) | ↓ | 5 | 10−6 | |||
NOS2 | see [110] | gtataaatac | \( \frac{\mathbf{t}}{c} \) | tcttggctgc | \( \frac{\mathbf{2}}{1} \) | ↑ | 3 | 10−2 | Resistance to malaria, epilepsy risk, and also, (hypothetically) drug-resistant or childhood epilepsy is associated with aggressiveness; stigma as a critical factor for interictal aggression in epilepsy (clinical review); aggression, hyperactivity, and impaired memory coexist during recurrent spontaneous seizures in epilepsy (rat model), gender-biased complication of excessive lead (Pb) intake manifested as lesser exploration in females and higher aggressiveness in males (mice) | |