Table 3 Candidate SNP markers of aggressiveness as a symptom of hereditary diseases (these markers may change the TBP–DNA affinity)
Gene | dbSNP [12] or see [Reference] | 5′ flank | \( \frac{\mathbf{wt}}{mut} \) | 3′ flank | KD, nM | Z-score | Known diseases (observations) [Reference] or hypothetical ones in the case of the candidate SNP markers predicted by us in [this work] (see Methods: Additional file 2 : Figure S1) | [Ref] or [this work] | ||
|---|---|---|---|---|---|---|---|---|---|---|
\( \frac{\mathbf{wt}}{mut} \) | Δ | Z | α | |||||||
ESR2 | rs35036378 | cctctcggtc | \( \frac{\mathbf{t}}{g} \) | ttaaaaggaa | \( \frac{\mathbf{6}}{8} \) | ↓ | 5 | 10−3 | ESR2-deficient pT1 tumor, | [116] |
(hypothetically) ESR2-deficient maladaptive aggressive social behaviors caused by bisphenol A and phthalates in children (primary tumors and aggression are well-known consequences of environmental pollution with bisphenol A) | ||||||||||
rs766797386 | ttaaaaggaa | \( \frac{\mathbf{g}}{t} \) | aaggggctta | \( \frac{\mathbf{6}}{7} \) | ↓ | 3 | 10−2 | |||
HBB | rs397509430 | gggctgggca | \( \frac{\mathbf{t}}{-} \) | atacaacagt | \( \frac{\mathbf{5}}{29} \) | ↓ | 34 | 10−6 | Malaria resistance, thalassemia, and also (hypothetically) thalassemia-related higher male–male aggression, socialized aggression, inattention, low IQ, acute psychosis with aggression, impulsiveness as a form of aggressiveness; aggression as a comorbidity in 4-yo and 5-yo girls and in boys with thalassemia in a hospital; aggressiveness as a consequence of regular hemodialysis in a severe form of thalassemia | |
rs33980857 | gggctgggca | \( \frac{\mathbf{t}}{a,g,c} \) | atacaacagt | \( \frac{\mathbf{5}}{21} \) | ↓ | 27 | 10−6 | |||
rs34598529 | ggctgggcat | \( \frac{\mathbf{a}}{g} \) | aaagtcaggg | \( \frac{\mathbf{5}}{18} \) | ↓ | 24 | 10−6 | |||
rs33931746 | gctgggcata | \( \frac{\mathbf{a}}{g,c} \) | aagtcagggc | \( \frac{\mathbf{5}}{11} \) | ↓ | 14 | 10−6 | |||
rs33981098 | agggctgggc | \( \frac{\mathbf{a}}{g,c} \) | taaaagtcag | \( \frac{\mathbf{5}}{9} \) | ↓ | 10 | 10−6 | |||
rs34500389 | cagggctggg | \( \frac{\mathbf{c}}{a,t,g} \) | ataaaagtca | \( \frac{\mathbf{5}}{6} \) | ↓ | 3 | 10−2 | |||
(HBD) | rs35518301 | caggaccagc | \( \frac{\mathbf{a}}{g} \) | taaaaggcag | \( \frac{\mathbf{4}}{8} \) | ↓ | 11 | 10−6 | ||
HBB | rs63750953 | ctgggcataa | \( \frac{\mathbf{aa}}{-} \) | gtcagggcag | \( \frac{\mathbf{5}}{8} \) | ↓ | 9 | 10 −6 | (hypothetically)malaria resistance, thalassemia, thalassemia-related higher male–male aggression, socialized aggression, inattention, low IQ, acute psychosis with aggression, impulsiveness as a form of aggressiveness; aggression as a comorbidity in 4-yo and 5-yo girls and in boys with thalassemia in a hospital; aggressiveness as a consequence of regular hemodialysis in a severe form of thalassemia | |
rs281864525 | tgggcataaa | \( \frac{\mathbf{a}}{c} \) | gtcagggcag | \( \frac{\mathbf{5}}{7} \) | ↓ | 7 | 10 −6 | |||
(HBD) | rs34166473 | aggaccagca | \( \frac{\mathbf{t}}{c} \) | aaaaggcagg | \( \frac{\mathbf{4}}{8} \) | ↓ | 18 | 10 −6 | ||