Table 1 Genes differentially expressed in ISIAH and WAG adrenal glands and referred to in Rat Genome Database as associated with hypertension

Ada

24165

0.75

adenosine deaminase

Adipoq ^a

246253

1.10

adiponectin, C1Q and collagen domain containing

Adrb3 ^a

25645

2.44

adrenergic, beta-3-, receptor

Agt ^a

24179

2.28

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

Alas1

65155

0.75

aminolevulinate, delta-, synthase 1

Alox5

25290

−0.83

arachidonate 5-lipoxygenase

Anxa3

25291

0.69

annexin A3

Aqp1

25240

−0.49

aquaporin 1

Atp1a2 ^a

24212

1.26

ATPase, Na+/K+ transporting, alpha 2 polypeptide

Avpr1a

25107

1.12

arginine vasopressin receptor 1A

Bche ^a

65036

1.32

butyrylcholinesterase

C1qb

29687

0.61

complement component 1, q subcomponent, B chain

C3 ^a

24232

2.06

complement component 3

Cd36 ^a

29184

1.04

CD36 molecule (thrombospondin receptor)

Cdkn2b

25164

−0.85

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Cdo1

81718

−1.20

cysteine dioxygenase, type I

Cfh

155012

0.76

complement factor H

Col1a1

29393

0.80

collagen, type I, alpha 1

Crp ^a

25419

detected only in ISIAH rats

C-reactive protein, pentraxin-related

Cx3cr1

171056

0.75

chemokine (C-X3-C motif) receptor 1

Cxcl10

245920

−1.90

chemokine (C-X-C motif) ligand 10

Cyba ^a

79129

0.68

cytochrome b-245, alpha polypeptide

Dusp1

114856

−0.94

dual specificity phosphatase 1

Ednrb

50672

0.82

endothelin receptor type B

Egr1

24330

−0.92

early growth response 1

Entpd2

64467

0.84

ectonucleoside triphosphate diphosphohydrolase 2

Ephx2 ^a

65030

4.37

epoxide hydrolase 2, cytoplasmic

F2r

25439

0.53

coagulation factor II (thrombin receptor

F5

304929

0.62

coagulation factor V (proaccelerin, labile factor)

Fabp1

24360

detected only in ISIAH rats

fatty acid binding protein 1, liver

Fas

246097

−0.80

Fas (TNF receptor superfamily, member 6)

Fbn1

83727

0.69

fibrillin 1

Fmo3

84493

0.57

flavin containing monooxygenase 3

Fn1

25661

0.76

fibronectin 1

Gabbr1

81657

1.11

gamma-aminobutyric acid (GABA) B receptor 1

Gstm2

24424

−0.60

glutathione S-transferase mu 2

Gstp1

24426

−0.53

glutathione S-transferase pi 1

Hdac4

363287

0.73

histone deacetylase 4

Hmgb1

25459

−0.84

high mobility group box 1

Hmgcr ^a

25675

0.63

3-hydroxy-3-methylglutaryl-CoA reductase

Hmox1 ^a

24451

−0.69

heme oxygenase (decycling) 1

Hp ^a

24464

1.10

haptoglobin

Hsd11b2

25117

−1.47

hydroxysteroid 11-beta dehydrogenase 2

Hyal1

367166

0.49

hyaluronoglucosaminidase 1

Igf1

24482

−2.12

insulin-like growth factor 1

Itgav ^a

296456

−0.58

integrin, alpha V

Loxl1

315714

0.50

lysyl oxidase-like 1

Lpl ^a

24539

0.52

lipoprotein lipase

Mpo

303413

4.46

myeloperoxidase

Nov

81526

−0.88

nephroblastoma overexpressed gene

Pik3r1 ^a

25513

0.50

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Postn

361945

1.30

periostin, osteoblast specific factor

Pparg ^a

25664

1.01

peroxisome proliferator-activated receptor gamma

Prkcb ^a

25023

0.90

protein kinase C, beta

Retn ^a

246250

2.26

resistin

Rgs5

54294

−0.85

regulator of G-protein signaling 5

RT1-Ba

309621

0.49

RT1 class II, locus Ba

RT1-Db1

294270

0.91

RT1 class II, locus Db1

S100b

25742

−1.72

S100 calcium binding protein B

Serpina1 ^a

24648

0.77

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin, member 1

Serpine1 ^a

24617

−2.04

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Serpine2

29366

2.19

serpin peptidase inhibitor, clade E, member 2

Slc4a4

84484

0.96

solute carrier family 4, sodium bicarbonate cotransporter, member 4

Slc8a1

29715

0.58

solute carrier family 8 (sodium/calcium exchanger), member 1

Slc9a3

24784

4.24

solute carrier family 9 (sodium/hydrogen exchanger), member 3

Sod2

24787

0.75

superoxide dismutase 2, mitochondrial

Spp1

25353

−0.56

secreted phosphoprotein 1

Tacr2

25007

0.84

tachykinin receptor 2

Tap1

24811

0.84

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Tek

89804

0.49

TEK tyrosine kinase, endothelial

Tnc

116640

1.74

tenascin C

Trpc6

89823

0.85

transient receptor potential cation channel, subfamily C, member 6

Ucp1 ^a

24860

detected only in ISIAH rats

uncoupling protein 1 (mitochondrial, proton carrier)

Vcam1 ^a

25361

0.78

vascular cell adhesion molecule 1

Vip

117064

−1.57

vasoactive intestinal peptide

Xdh

497811

−0.88

xanthine dehydrogenase