The influence of pro-longevity gene Gclc overexpression on the age-dependent changes in Drosophila transcriptome and biological functions

Table 1 Influence of Gclc overexpression on median and maximum lifespan (the results of 3 replicates are combined)

Genotype	Sex	M (days)	dM	Gehan-Wilcoxon test (p-value)	90% (days)	d90%	Wang-Allison test (p-value)	n
UAS-Gclc (control)	males	50			72			449
Appl-GAL4 > UAS-Gclc (overexpression)	males	65	+23.1%	p < 0.0001 (0)	76	+5.3%	p < 0.001 (0.00014)	419
UAS-Gclc (control)	females	53			72			464
Appl-GAL4 > UAS-Gclc (overexpression)	females	76	+30.3%	p < 0.0001 (0)	88	+18.2%	p < 0.0001 (0)	390

M - median lifespan, 90% - age of 90% mortality (maximum lifespan), dM - differences between median lifespan of control and Gclc overexpressed flies, d90% - differences between age of 90% mortality of control and Gclc overexpressed flies, n - number of flies

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